There are
690 mi
from St Charles, MO to Pascagoula, MS
That's the driving distance. It would take 12 hours 53 mins to go from St Charles, Missouri to Pascagoula, Mississippi.
The flight distance (direct flight from St Charles, MO to Pascagoula, MS) is 592.46 mi.
690 mi = 1,109.85 kms