There are
2,064 mi
from St Charles, MO to Palo Alto, CA
That's the driving distance. It would take 1 day 11 hours to go from St Charles, Missouri to Palo Alto, California.
The flight distance (direct flight from St Charles, MO to Palo Alto, CA) is 1,713.44 mi.
2,064 mi = 3,322.26 kms