There are
361 mi
from St Charles, MO to Nicholasville, KY
That's the driving distance. It would take 6 hours 52 mins to go from St Charles, Missouri to Nicholasville, Kentucky.
The flight distance (direct flight from St Charles, MO to Nicholasville, KY) is 327.86 mi.
361 mi = 580.22 kms