There are
1,593 mi
from St Charles, MO to Missoula, MT
That's the driving distance. It would take 1 day 3 hours to go from St Charles, Missouri to Missoula, Montana.
The flight distance (direct flight from St Charles, MO to Missoula, MT) is 1,308.65 mi.
1,593 mi = 2,563.20 kms