There are
1,495 mi
from St Charles, MO to Mesquite, NV
That's the driving distance. It would take 1 day 1 hour to go from St Charles, Missouri to Mesquite, Nevada.
The flight distance (direct flight from St Charles, MO to Mesquite, NV) is 1,289.72 mi.
1,495 mi = 2,405.80 kms