There are
2,005 mi
from St Charles, MO to Manteca, CA
That's the driving distance. It would take 1 day 10 hours to go from St Charles, Missouri to Manteca, California.
The flight distance (direct flight from St Charles, MO to Manteca, CA) is 1,658.61 mi.
2,005 mi = 3,226.49 kms