There are
1,970 mi
from St Charles, MO to Lompoc, CA
That's the driving distance. It would take 1 day 10 hours to go from St Charles, Missouri to Lompoc, California.
The flight distance (direct flight from St Charles, MO to Lompoc, CA) is 1,675.52 mi.
1,970 mi = 3,170.83 kms