Miles between St Charles, MO and Brookings, SD

There are
645 mi
from St Charles, MO to Brookings, SD

That's the driving distance. It would take 11 hours 41 mins to go from St Charles, Missouri to Brookings, South Dakota.

The flight distance (direct flight from St Charles, MO to Brookings, SD) is 500.95 mi.

645 mi = 1,037.73 kms