There are
1,645 mi
from St Charles, MO to Blythe, CA
That's the driving distance. It would take 1 day 4 hours to go from St Charles, Missouri to Blythe, California.
The flight distance (direct flight from St Charles, MO to Blythe, CA) is 1,384.61 mi.
1,645 mi = 2,646.88 kms