There are
1,683 mi
from South San Francisco, CA to Yankton, SD
That's the driving distance. It would take 1 day 5 hours to go from South San Francisco, California to Yankton, South Dakota.
The flight distance (direct flight from South San Francisco, CA to Yankton, SD) is 1,361.39 mi.
1,683 mi = 2,707.96 kms