There are
2,881 mi
from South San Francisco, CA to Lansdowne, PA
That's the driving distance. It would take 2 days 2 hours to go from South San Francisco, California to Lansdowne, Pennsylvania.
The flight distance (direct flight from South San Francisco, CA to Lansdowne, PA) is 2,513.53 mi.
2,881 mi = 4,637.10 kms