There are
2,522 mi
from South San Francisco, CA to Ironton, OH
That's the driving distance. It would take 1 day 20 hours to go from South San Francisco, California to Ironton, Ohio.
The flight distance (direct flight from South San Francisco, CA to Ironton, OH) is 2,143.93 mi.
2,522 mi = 4,058.24 kms