There are
433 mi
from South Bend, IN to Cape Girardeau, MO
That's the driving distance. It would take 8 hours 9 mins to go from South Bend, Indiana to Cape Girardeau, Missouri.
The flight distance (direct flight from South Bend, IN to Cape Girardeau, MO) is 348.99 mi.
433 mi = 697.47 kms