There are
826 mi
from Sioux Falls, SD to Ypsilanti, MI
That's the driving distance. It would take 15 hours 4 mins to go from Sioux Falls, South Dakota to Ypsilanti, Michigan.
The flight distance (direct flight from Sioux Falls, SD to Ypsilanti, MI) is 667.88 mi.
826 mi = 1,329.59 kms