There are
853 mi
from Sioux Falls, SD to Wyandotte, MI
That's the driving distance. It would take 15 hours 39 mins to go from Sioux Falls, South Dakota to Wyandotte, Michigan.
The flight distance (direct flight from Sioux Falls, SD to Wyandotte, MI) is 691.43 mi.
853 mi = 1,372.38 kms