There are
1,193 mi
from Sioux Falls, SD to Waynesville, NC
That's the driving distance. It would take 22 hours 1 min to go from Sioux Falls, South Dakota to Waynesville, North Carolina.
The flight distance (direct flight from Sioux Falls, SD to Waynesville, NC) is 916.85 mi.
1,193 mi = 1,920.25 kms