There are
427 mi
from Sioux Falls, SD to Waunakee, WI
That's the driving distance. It would take 7 hours 42 mins to go from Sioux Falls, South Dakota to Waunakee, Wisconsin.
The flight distance (direct flight from Sioux Falls, SD to Waunakee, WI) is 364.59 mi.
427 mi = 687.77 kms