There are
1,561 mi
from Sioux Falls, SD to Waterville, ME
That's the driving distance. It would take 1 day 7 hours to go from Sioux Falls, South Dakota to Waterville, Maine.
The flight distance (direct flight from Sioux Falls, SD to Waterville, ME) is 1,339.81 mi.
1,561 mi = 1.61 kms