There are
1,556 mi
from Sioux Falls, SD to Waltham, MA
That's the driving distance. It would take 1 day 4 hours to go from Sioux Falls, South Dakota to Waltham, Massachusetts.
The flight distance (direct flight from Sioux Falls, SD to Waltham, MA) is 1,285.05 mi.
1,556 mi = 1.61 kms