There are
1,176 mi
from Sioux Falls, SD to Tuskegee, AL
That's the driving distance. It would take 22 hours 17 mins to go from Sioux Falls, South Dakota to Tuskegee, Alabama.
The flight distance (direct flight from Sioux Falls, SD to Tuskegee, AL) is 972.11 mi.
1,176 mi = 1.61 kms