There are
1,645 mi
from Sioux Falls, SD to Titusville, FL
That's the driving distance. It would take 1 day 6 hours to go from Sioux Falls, South Dakota to Titusville, Florida.
The flight distance (direct flight from Sioux Falls, SD to Titusville, FL) is 1,356.25 mi.
1,645 mi = 1.61 kms