There are
1,629 mi
from Sioux Falls, SD to Tarpon Springs, FL
That's the driving distance. It would take 1 day 5 hours to go from Sioux Falls, South Dakota to Tarpon Springs, Florida.
The flight distance (direct flight from Sioux Falls, SD to Tarpon Springs, FL) is 1,316.08 mi.
1,629 mi = 1.61 kms