There are
524 mi
from Sioux Falls, SD to Sycamore, IL
That's the driving distance. It would take 9 hours 34 mins to go from Sioux Falls, South Dakota to Sycamore, Illinois.
The flight distance (direct flight from Sioux Falls, SD to Sycamore, IL) is 420.33 mi.
524 mi = 842.54 kms