Miles between Sioux Falls, SD and Sikeston, MO

There are
746 mi
from Sioux Falls, SD to Sikeston, MO

That's the driving distance. It would take 13 hours 38 mins to go from Sioux Falls, South Dakota to Sikeston, Missouri.

The flight distance (direct flight from Sioux Falls, SD to Sikeston, MO) is 594.01 mi.

746 mi = 1,199.99 kms