There are
371 mi
from Sioux Falls, SD to Shawnee, KS
That's the driving distance. It would take 6 hours 38 mins to go from Sioux Falls, South Dakota to Shawnee, Kansas.
The flight distance (direct flight from Sioux Falls, SD to Shawnee, KS) is 329.31 mi.
371 mi = 596.52 kms