There are
1,646 mi
from Sioux Falls, SD to Seminole, FL
That's the driving distance. It would take 1 day 6 hours to go from Sioux Falls, South Dakota to Seminole, Florida.
The flight distance (direct flight from Sioux Falls, SD to Seminole, FL) is 1,332.90 mi.
1,646 mi = 1.61 kms