There are
1,800 mi
from Sioux Falls, SD to Santa Cruz, CA
That's the driving distance. It would take 1 day 7 hours to go from Sioux Falls, South Dakota to Santa Cruz, California.
The flight distance (direct flight from Sioux Falls, SD to Santa Cruz, CA) is 1,404.18 mi.
1,800 mi = 1.61 kms