There are
1,350 mi
from Sioux Falls, SD to Sanford, NC
That's the driving distance. It would take 1 day 1 hour to go from Sioux Falls, South Dakota to Sanford, North Carolina.
The flight distance (direct flight from Sioux Falls, SD to Sanford, NC) is 1,084.37 mi.
1,350 mi = 2,172.40 kms