There are
1,607 mi
from Sioux Falls, SD to Sanford, FL
That's the driving distance. It would take 1 day 5 hours to go from Sioux Falls, South Dakota to Sanford, Florida.
The flight distance (direct flight from Sioux Falls, SD to Sanford, FL) is 1,330.73 mi.
1,607 mi = 1.61 kms