There are
718 mi
from Sioux Falls, SD to Saginaw, MI
That's the driving distance. It would take 14 hours 42 mins to go from Sioux Falls, South Dakota to Saginaw, Michigan.
The flight distance (direct flight from Sioux Falls, SD to Saginaw, MI) is 638.58 mi.
718 mi = 1,155.41 kms