There are
1,633 mi
from Sioux Falls, SD to Safety Harbor, FL
That's the driving distance. It would take 1 day 6 hours to go from Sioux Falls, South Dakota to Safety Harbor, Florida.
The flight distance (direct flight from Sioux Falls, SD to Safety Harbor, FL) is 1,327.21 mi.
1,633 mi = 1.61 kms