There are
1,230 mi
from Sioux Falls, SD to Pascagoula, MS
That's the driving distance. It would take 22 hours 59 mins to go from Sioux Falls, South Dakota to Pascagoula, Mississippi.
The flight distance (direct flight from Sioux Falls, SD to Pascagoula, MS) is 1,014.62 mi.
1,230 mi = 1.61 kms