There are
1,325 mi
from Sioux Falls, SD to Panama City, FL
That's the driving distance. It would take 1 day 1 hour to go from Sioux Falls, South Dakota to Panama City, Florida.
The flight distance (direct flight from Sioux Falls, SD to Panama City, FL) is 1,106.18 mi.
1,325 mi = 1.61 kms