There are
1,332 mi
from Sioux Falls, SD to Panama City Beach, FL
That's the driving distance. It would take 1 day 1 hour to go from Sioux Falls, South Dakota to Panama City Beach, Florida.
The flight distance (direct flight from Sioux Falls, SD to Panama City Beach, FL) is 1,100.76 mi.
1,332 mi = 1.61 kms