There are
1,658 mi
from Sioux Falls, SD to Palmetto, FL
That's the driving distance. It would take 1 day 6 hours to go from Sioux Falls, South Dakota to Palmetto, Florida.
The flight distance (direct flight from Sioux Falls, SD to Palmetto, FL) is 1,358.65 mi.
1,658 mi = 1.61 kms