There are
819 mi
from Sioux Falls, SD to Owensboro, KY
That's the driving distance. It would take 15 hours 8 mins to go from Sioux Falls, South Dakota to Owensboro, Kentucky.
The flight distance (direct flight from Sioux Falls, SD to Owensboro, KY) is 641.13 mi.
819 mi = 1,317.68 kms