There are
374 mi
from Sioux Falls, SD to Ottumwa, IA
That's the driving distance. It would take 6 hours 47 mins to go from Sioux Falls, South Dakota to Ottumwa, Iowa.
The flight distance (direct flight from Sioux Falls, SD to Ottumwa, IA) is 280.63 mi.
374 mi = 601.44 kms