There are
1,600 mi
from Sioux Falls, SD to Newburyport, MA
That's the driving distance. It would take 1 day 5 hours to go from Sioux Falls, South Dakota to Newburyport, Massachusetts.
The flight distance (direct flight from Sioux Falls, SD to Newburyport, MA) is 1,296.78 mi.
1,600 mi = 1.61 kms