There are
1,604 mi
from Sioux Falls, SD to New Port Richey, FL
That's the driving distance. It would take 1 day 5 hours to go from Sioux Falls, South Dakota to New Port Richey, Florida.
The flight distance (direct flight from Sioux Falls, SD to New Port Richey, FL) is 1,311.58 mi.
1,604 mi = 1.61 kms