There are
1,045 mi
from Sioux Falls, SD to Murrysville, PA
That's the driving distance. It would take 19 hours 8 mins to go from Sioux Falls, South Dakota to Murrysville, Pennsylvania.
The flight distance (direct flight from Sioux Falls, SD to Murrysville, PA) is 897.66 mi.
1,045 mi = 1.61 kms