There are
854 mi
from Sioux Falls, SD to Mesquite, TX
That's the driving distance. It would take 15 hours 5 mins to go from Sioux Falls, South Dakota to Mesquite, Texas.
The flight distance (direct flight from Sioux Falls, SD to Mesquite, TX) is 745.07 mi.
854 mi = 1,374.13 kms