There are
508 mi
from Sioux Falls, SD to Mequon, WI
That's the driving distance. It would take 9 hours 21 mins to go from Sioux Falls, South Dakota to Mequon, Wisconsin.
The flight distance (direct flight from Sioux Falls, SD to Mequon, WI) is 437.69 mi.
508 mi = 816.80 kms