There are
564 mi
from Sioux Falls, SD to Melrose Park, IL
That's the driving distance. It would take 10 hours 13 mins to go from Sioux Falls, South Dakota to Melrose Park, Illinois.
The flight distance (direct flight from Sioux Falls, SD to Melrose Park, IL) is 462.86 mi.
564 mi = 907.93 kms