There are
292 mi
from Sioux Falls, SD to Maryville, MO
That's the driving distance. It would take 5 hours 27 mins to go from Sioux Falls, South Dakota to Maryville, Missouri.
The flight distance (direct flight from Sioux Falls, SD to Maryville, MO) is 240.45 mi.
292 mi = 470.09 kms