There are
1,214 mi
from Sioux Falls, SD to Martinsburg, WV
That's the driving distance. It would take 22 hours 20 mins to go from Sioux Falls, South Dakota to Martinsburg, West Virginia.
The flight distance (direct flight from Sioux Falls, SD to Martinsburg, WV) is 1,007.44 mi.
1,214 mi = 1.61 kms