There are
524 mi
from Sioux Falls, SD to Manitowoc, WI
That's the driving distance. It would take 9 hours 50 mins to go from Sioux Falls, South Dakota to Manitowoc, Wisconsin.
The flight distance (direct flight from Sioux Falls, SD to Manitowoc, WI) is 452.11 mi.
524 mi = 843.13 kms