There are
1,631 mi
from Sioux Falls, SD to Loma Linda, CA
That's the driving distance. It would take 1 day 4 hours to go from Sioux Falls, South Dakota to Loma Linda, California.
The flight distance (direct flight from Sioux Falls, SD to Loma Linda, CA) is 1,281.91 mi.
1,631 mi = 1.61 kms