There are
1,368 mi
from Sioux Falls, SD to Lexington, SC
That's the driving distance. It would take 1 day 1 hour to go from Sioux Falls, South Dakota to Lexington, South Carolina.
The flight distance (direct flight from Sioux Falls, SD to Lexington, SC) is 1,060.53 mi.
1,368 mi = 1.61 kms