There are
949 mi
from Sioux Falls, SD to Lexington, KY
That's the driving distance. It would take 17 hours 8 mins to go from Sioux Falls, South Dakota to Lexington, Kentucky.
The flight distance (direct flight from Sioux Falls, SD to Lexington, KY) is 741.78 mi.
949 mi = 1,527.34 kms