There are
375 mi
from Sioux Falls, SD to Lenexa, KS
That's the driving distance. It would take 6 hours 42 mins to go from Sioux Falls, South Dakota to Lenexa, Kansas.
The flight distance (direct flight from Sioux Falls, SD to Lenexa, KS) is 333.58 mi.
375 mi = 603.84 kms